San Francisco quarterback Brock Purdy was a limited participant in practice Wednesday and has a chance to play on Sunday, 49ers coach Kyle Shananah said.
Toe and shoulder injuries kept Purdy on the sideline for San Francisco’s 26-21 win at New Orleans last week. He has a form of turf toe and was expected to miss multiple weeks. In a spot start, backup Mac Jones completed 26 of 39 passes for 279 yards and three touchdowns without an interception.
The 49ers (2-0) play their home opener on Sunday against the Arizona Cardinals (2-0).
Purdy, 25, is nursing left shoulder and toe ailments after completing 26 of 35 passes for 277 yards, two TDs and two interceptions in the season-opening 17-13 victory at the Seattle Seahawks.
San Francisco placed starting left guard Ben Bartch on injured reserve on Wednesday due to a high ankle sprain. The team promoted tight end Brayden Willis to the active roster and signed offensive lineman Brandon Parker to the practice squad.
Shanahan also said guard Spencer Burford (knee), defensive end Yetur Gross-Matos (knee), fullback Kyle Juszczyk (concussion) and safety Siran Neal (concussion) will sit out practice.
Wednesday is a scheduled rest day for defensive end Nick Bosa, running back Christian McCaffrey and left tackle Trent Williams.